Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

Highlights•MiTEs are novel myeloid-targeted immunocytokine prodrugs for cancer immunotherapy•TREM2 antagonis…

Lymphoid gene expression supports neuroprotective microglia function

PU.1 expression in microglia is regulated not only genetically but also epigenetically by the microenvironment…

Niche-specific dermal macrophage loss promotes skin capillary ageing

AbstractAll mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tis…

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

Efferocytosis-associated reprogramming of the islet macrophages and the subsequent influence on the adaptive i…

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunoregulatory mo-macs in the…