Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer

Highlights•Spatial multi-omics maps cachexia progression in pancreatic cancer•SEMA4A+ tumor cells associate …

CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer

Highlights•An AI-designed IL-21 mimic synergizes with KRASi in KRAS-mutant cancer models•Durable remissions …

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

AbstractSystemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs). Alth…

Persistent and transient senescent cells contribute to brain-barrier development

Highlights•Distinct senescent states arise across brain-barrier cell lineages•Endothelial cells and macropha…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human

Highlights•cMAF is essential for the specification of brain perivascular macrophages (PVMs)•cMAF supports ce…