Sustaining microglial reparative function enhances stroke recovery

AbstractNeurological symptoms after brain injury can remain as lifelong detrimental sequelae because most of t…

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis

INTRODUCTIONThe brain governs sexual maturation, pubertal development, and fertility through a hormonal commun…

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

AbstractAgeing is accompanied by declining memory function, with extremely heterogeneous manifestation in the …

Early fibrotic niches establish tumour-permissive microenvironments

AbstractPathologic transformation represents a critical yet poorly defined window during which mutant epitheli…

Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity

INTRODUCTIONMacrophages in the tumor microenvironment exert antitumorigenic effects through phagocytosis and/o…