Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

AbstractBody–brain communication has emerged as a key regulator of tissue homeostasis. Solid tumours are inne…

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors

INTRODUCTIONIn vivo delivery systems (IDSs) are essential for enabling the clinical use of therapeutic agents …

Intestinal interoceptive dysfunction drives age-associated cognitive decline

AbstractAgeing is accompanied by declining memory function, with extremely heterogeneous manifestation in the …

Mucosal vaccination in mice provides protection from diverse respiratory threats

An intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 ligands with a model antigen,…

Intestinal macrophages modulate synucleinopathy along the gut–brain axis

ME-Macs as early cellular initiators of αS pathology along the gut–brain axis. Understanding these mechanism…