Mutation-dependent responses to sleep and exercise in clonal haematopoiesis

AbstractClonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whethe…

Somatic mutations reveal the ontogeny of microglia in human ageing

AbstractMicroglia are the resident macrophages of the central nervous system. In mice, microglia seed the brai…

Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

Structured AbstractINTRODUCTIONAging is accompanied by parallel functional decline across organs, but the cell…

ILC2s regulate a fibroblast progenitor niche in the pancreas

Structured AbstractINTRODUCTIONFibroblasts are central regulators of organ health and disease, although it rem…

CD4+ T cells impair tumor growth through IL-3 and TNF-dependent vascular damage

INTRODUCTIONCancer cells typically produce molecules (antigens) that are distinct from those made by normal ce…