Intestinal macrophages modulate synucleinopathy along the gut–brain axis

ME-Macs as early cellular initiators of αS pathology along the gut–brain axis. Understanding these mechanism…

Convergent evolution of scavenger cell development at brain borders

muLECs and BAMs share functional analogies but are not homologous, providing an example of convergent evolutio…

The transition from monocyte to tissue-resident macrophage requires DHPS

A cell-intrinsic, tissue-agnostic pathway that drives differentiation of monocyte-derived macrophages into RTM…

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

AbstractObesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obes…

Branched actin networks mediate macrophage-dependent host-microbiota homeostasis

The indispensable role of ARPC5-containing, but not ARPC5L-containing, Arp2/3 complexes in mononuclear phagocy…